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The Primary Article On Exchange

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Next-technology sequencing of T and B cell receptor repertoires from COVID-19 patients showed signatures associated with severity of illness. Seasonal human coronavirus antibodies are boosted upon SARS-CoV-2 infection however not related to safety. West, A. P. Jr., Diskin, R., Nussenzweig, M. C. & Bjorkman, P. J. Structural basis for germ-line gene usage of a potent class of antibodies targeting the CD4-binding site of HIV-1 gp120. Viral variants that provoke and drive maturation of V1V2-directed HIV-1 broadly neutralizing antibodies. Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies. Structures of human antibodies bound to SARS-CoV-2 spike reveal common epitopes and recurrent features of antibodies. Immunogenicity and buildings of a rationally designed prefusion MERS-CoV spike antigen. The sera confirmed minimal or no reactivity to SARS-CoV-2/CoV-1 and MERS-CoV spikes but confirmed strong binding to the endemic HCoV spikes, particularly in opposition to the HCoV-HKU1 and HCoV-OC43 β-HCoVs (Fig. 1, Supplementary Fig. 1). The outcomes suggest that the pre-pandemic sera, at least in our cohort, possess low ranges of pre-existing SARS-CoV-2-circulating Abs.


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